Microchimerism
Pregnancy
results in the transfer of a low number of cells from the fetus to the mother
(Dubernard et al., 2009). these cells can persist in maternal blood or tissue
for decades ,creating a state of physiological microchimerism in the porous
woman.(khosrotehrani et al., 2004).
II
Microchimerism
result when two genetically disparate population of cells appear in the same
tissue, organ or individual.(Leduc et al., 2012)
Foetal
microchimeric cells have been reported to contain progenitor cells. (castela et al., 2017) including:
·
Lymphoid
·
hematopoietic
·
Mesenchymal
·
Cardiomyocyte
Foetal
cells nest in maternal bone marrow and remain well tolerated by the maternal
immune system. (castela et al., 2017).
.
(Bianchi et al., 2004).
Foetal
The fetal cell microchimerism may be relatively common occurrence in women with
both autoimmune and non-autoimmune diseases.microchemeric cells are able to
differentiate into:
·
Neurons
·
Hepatocytes
·
Endothelial
cells
Maternal
skin recruits foetal microchimeric cells through Ccr2 signaling.( castela et
al.,2017).
The Ccr2 ligand chemokine ligand 2 (Ccl2) enhance the recruitment
of FMCs to maternal wound where these cells transdifferentiate into endothelial
cells and stimulate angiogenesis. . (castela et al., 2017).
Microchimerism cells have both advantages and disadvantages on the
pregnant women the question here is if we inhabit the production of these cells
during pregnancy what will happens to the pregnant women?
Castela, M; Nassar, D; Sbeih, M;
Jachiet, M; Wang, Z; Aractingi, S. (2017). Ccl2/Ccr2 signalling recruits a distinct
fetalmicrochimeric population that rescues delayed maternal wound healing. Natural
communication. 8:15463. DOI: 10.1038/ncomms15463.