Microchimerism           

Pregnancy results in the transfer of a low number of cells from the fetus to the mother (Dubernard et al., 2009). these cells can persist in maternal blood or tissue for decades ,creating a state of physiological microchimerism in the porous woman.(khosrotehrani et al., 2004).

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     Microchimerism result when two genetically disparate population of cells appear in the same tissue, organ or individual.(Leduc et al., 2012)

     Foetal microchimeric cells have been reported to contain progenitor cells.  (castela et al., 2017) including:

·         Lymphoid

·          hematopoietic

·         Mesenchymal

·         Cardiomyocyte

     Foetal cells nest in maternal bone marrow and remain well tolerated by the maternal immune system. (castela et al., 2017).

.     (Bianchi et al., 2004).

     Foetal The fetal cell microchimerism may be relatively common occurrence in women with both autoimmune and non-autoimmune diseases.microchemeric cells are able to differentiate into:

·         Neurons

·         Hepatocytes

·         Endothelial cells

     Maternal skin recruits foetal microchimeric cells through Ccr2 signaling.( castela et al.,2017).

The Ccr2 ligand chemokine ligand 2 (Ccl2) enhance the recruitment of FMCs to maternal wound where these cells transdifferentiate into endothelial cells and stimulate angiogenesis. . (castela et al., 2017).

Microchimerism cells have both advantages and disadvantages on the pregnant women the question here is if we inhabit the production of these cells during pregnancy what will happens to the pregnant women? 

Castela, M; Nassar, D; Sbeih, M; Jachiet, M; Wang, Z; Aractingi, S. (2017).    Ccl2/Ccr2 signalling recruits a distinct fetalmicrochimeric population that rescues delayed maternal wound healing. Natural communication. 8:15463. DOI: 10.1038/ncomms15463.